Viscosity vs. Concentration

L-Arginine is an amino acid widely used in biologics to reduce the viscosity of high concentration antibody solutions and to improve solubility

The exact mechanism by which Arginine molecules affect protein molecules in solution is unclear. Nonetheless, its benefits increasing solubility and controlling viscosity have spread out its application in biopharma formulations, specially for high concentration antibody solutions. 

In this application note, we examine the effect of concentration on the viscosity of dilute solutions of L-Arginine in water and PBS. Additionally, we study the Intrinsic Viscosity of this solutions to better understand molecular size and solubility in dilution. 

These results demonstrate the advantages of VROC^® powered viscometers:

• Superior repeatability (0.5% of Reading) and accuracy (2% of Reading) of precise measuremens of Intrinsic and Dynamic Viscosity

• High throughput with fast and reliable measurements

• Our viscometers DO NOT require cleaning between miscible samples!