We frequently get the question, "how do I know that my equipment is working, or that these tests are accurate?" The best way to determine this and be sure of your results is to run a system suitability test.
We are all familiar with maintaining our lab instruments, but how often do we perform maintenance on our lab methods or SOPs?
In the upcoming weeks, we are proud to announce the release of our latest application note regarding concentration dependence in protein viscosity. In this app note, Dr. Stacey Elliott gathered viscosity data for Bovine Gamma Globulin (BgG) formulations over the full concentration range, including therapeutic levels ≥ 100 mg/mL, using the VROC®Initium. The solution buffer included sucrose which is a common additive to enhance stabilization during freeze-drying and storage. Relative viscosity versus concentration curves were fit with the Ross-Minton equation which is a frequently used analysis tool for protein formulations.
To view application note, click below!
Measuring viscosity dates back to as early as the 19th century. French physicist Jean Poiseuille discovered the concept of measuring viscosity by formulating the "mathematical expression for the flow rate for the laminar flow of fluids in circular tubes." Later on, this formulation was discovered by a German hydraulic engineer Gotthilf Hagen, which came to be known as the Hagen-Poiseuille equation (Britannica). Early measurements of viscosity focused primarily on the flow of blood. Measurements were conducted using the hemodynamometer that incorporated narrow tubes & glass capillaries in effort to measure the pressures in the arteries of horses and dogs (Sutera).
The workshop will take place at the Hyatt Regency in Cambridge, Massachusetts. We will include a demonstration of the instrument, along with a presentation and Q&A session on how automated shear rate/temperature sweeps can help characterize your samples.
The exact mechanism by which Arginine molecules affect protein molecules in solution is unclear. Nonetheless, its benefits increasing solubility and controlling viscosity have spread out its application in biopharma formulations, specially for high concentration antibody solutions.
In our application note, we examine the effect of concentration on the viscosity of dilute solutions of L-Arginine in water and PBS. Additionally, we study the Intrinsic Viscosity of this solutions to better understand molecular size and solubility in dilution.
The workshop will take place at the Kenilworth Inn in New Jersey. We will include a demonstration of the instrument, along with a presentation and Q&A session on how automated shear rate/temperature sweeps can help characterize your samples.
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