Ebook - Predicting Injection Force

Viscosity is an important fluid property that can be used to predict performance in real world applications. One of the most common uses of viscosity is to assess the ability to deliver pharmaceutical formulations to the patient by injection. However, a key limitation for antibody therapeutics is the high concentrations necessary to achieve an effective dose. High concentrations of protein lead to large increases in viscosity, which can make injection more difficult. Depending on the device used for injection, the cutoff viscosity of the formulation can be between 20 and 40 centipoise. A significant component of formulation research and development is rheology modification to ensure that therapeutics can be delivered without an excessive injection force.

Download our Predicting Injection Force eBook for a complete guide to predicting injection force from theoretical foundation to protocols you can follow to estimate the injection force of Newtonian and non-Newtonian fluids.