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Not doing stability studies? Here's why you should.

February 18, 2020

Protein stability and understanding how your proteins will work is important. It is an important factor in research and development and in formulation. It's so important that there are departments dedicated specifically to the process. Researchers focus on stabilizing proteins so that there will be no serious side effects in the final products that are developed.

Temperature is a critical aspect in protein formulation since an increase in temperature can cause protein to lose its tertiary and secondary structures. As it continues, proteins begin to aggregate and can cause small changes to viscosity. Proteins are complex, when molecules unfold and aggregate, the viscosity of protein could potentially increase. The increase in viscosity could cause potential issues, such as potentially creating pain for the patient taking the final drugs, or worse, create an immune response that leads to serious side effects.

Aside from the patient experience, drug efficacy and storage shelf life could also be severely impacted if you are not aware of how your proteins remain stable and also over how much period of time.

Protein stability can be impacted based on:

  • Temperature
  • pH
  • Concentration
  • & more!

In order to provide the researchers best solution to measure viscosity, RheoSense created  m-VROC™ viscometer detect these small changes using only a small sample. This makes m-VROC™ a useful tool to investigate drug stability without needing to dilute the sample. Some of the features of our instrument includes measurement of small sample volumes as low as 20µl, partial sample recovery, Temperature range from 4-100°C and it also improves particle size measurements. With this enhanced viscometer, it will be more accurate and reliable to measure viscosity.

Want to learn more about protein stability and viscosity? Check out our detailed web page on protein stability or download any of our protein stability application notes to get real life case studies and data. 

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