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Why is it important to do viscosity testing at greater than 1,000 1/s?

Posted by Rick Paulino on Mar 3, 2020 4:45:00 AM

If you are not performing high shear viscosity testing on your proteins, then you are not fully characterizing your samples.

Scientist Thinking

You may be missing valuable information that can shape, direct and influence your formulation.

Multiple Directions-min

 

App 32 (1-20) Figure b rev 1

Relative Viscosity vs. Shear Rate of 250 mg/ml BgG at (25°C)

•Complete shear rate profile

•Most shear thinning occurs at shear rates above 1,000 1/s

•Accurately estimate shear at the needle

•With knowledge of shear thinning

•Therapeutic concentration can be increased

•Needle gauge can be higher for increased patient comfort leading to greater patient compliance

•More accurate injection force calculations

App 32 (1-20) Figure a

Viscosity vs. Shear Rate of 250 mg/ml BgG at (25°C)

Complete characterization is fast and easy with RheoSense VROC® technology!

The importance of fully characterizing your sample cannot be underestimated.

You may be missing valuable information leading to missed deadlines and delay to market.

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