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Why you need to measure a full range of shear rates.

Posted by RheoSense on Aug 13, 2019 7:32:00 AM

In Applications, Viscometer, RheoSense, Inc.

A lot of my customers have admitted to measuring viscosity at a shear rate of 1,000 1/s when it comes to formulating various types of drugs including injectables. However, from our recent in-depth analysis of various salt concentrations added to proteins, our results further confirmed why you are not getting your full spectrum when it comes to measuring your proteins at just one and a low shear rate of 1,000 1/s.

  1. Viscosity measurement at wide shear rate range (low to high shear rates) probes Protein to protein interaction and set a better course to formulation optimization of protein therapeutics.    
  2. Accurate injectability estimation requires high shear rate viscosity measurement.  Need to measure viscosity not only at 1000 1/s but also at 100000 1/s.  

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BGG with Salt

Shear Rate Sweeps

Viscosity vs. Shear Rate Scaling Peclet Number