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RheoSense Blog: In Viscosity News...

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RheoSense Blog

Latest Release & Upcoming Events

Posted by Joseph Chun

May 15, 2018 1:00:00 PM

In the upcoming weeks, we are proud to announce the release of our latest application note regarding concentration dependence in protein viscosity. In this app note, Dr. Stacey Elliott gathered viscosity data for Bovine Gamma Globulin (BgG) formulations over the full concentration range, including therapeutic levels ≥ 100 mg/mL, using the VROC®Initium. The solution buffer included sucrose which is a common additive to enhance stabilization during freeze-drying and storage. Relative viscosity versus concentration curves were fit with the Ross-Minton equation which is a frequently used analysis tool for protein formulations.

To view application note, click below!

DOWNLOAD APPLICATION NOTE

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Topics: Viscosity Measurements, Protein Solutions, bovine gamma globulin, shear rate sweep, Announcement, viscosity, Fun with Viscosity, VROC Technology, RheoSense News, Small Sample Viscometer, Viscometer, General Information, Rheometer, Proteins

Impact of ph in Royal Jelly 

Posted by Joseph Chun

Mar 27, 2018 12:31:36 PM

According to Cell Press, "Royal jelly is produced in [two different] glands of worker bees, one that produces the protein in a neutral pH and one that produces fatty acids that can reduce said pH when the two secretions" come together (Cell Press).

For a honeybee, royal jelly is a crucial diet for the first couple days for all bees. And for honeybee larvae to become queen, the larvae must be fed and be surrounded by royal jelly for it to morph successfully. However, because queen larvae, "are too big to fit into the cells of the hive's honeycomb," they are able to hang upside down in the queen's cell anchored with the royal jelly (Cell Press). So, what allows this royal jelly to acquire these properties? 

Turns out, royal jelly is not always thick and sticky. In a recent study, researchers proposed that the viscosity of a royal jelly were dependent the particle size of a protein found in royal jelly (known as royalactin, or MRJP1) was directly correlated to the pH level found inside. The study conveyed that there was a noticeable size difference within the MRJP1 jelly when exposed to a purifier at pH 4 and at neutral (pH 7). For instance, "Most purification protocols are standardized at pH 7, [which yielded] a strange, runny consistency [within the jelly]" whereas when maintained between pH 4 and pH 5, the viscosity of the jelly seemed gelatinous and almost adherent (Cell Press). The precise pH affects the overall viscosity of royal jelly, which is an essential component in providing the optimal environment for the queen bee to develop in her early stages. If the pH levels were outside 4~5, the royal jelly would lose its heavy, sticky properties and would not be able to hold the queen larvae. 

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Topics: viscosity, Applications, Proteins, Viscosity Measurements, Fun with Viscosity

In the Blink of an Eye - Viscosity of Eye Drops

Posted by Joseph Chun

Jan 23, 2018 10:32:36 AM

Wow, it's already more than halfway through January within the new year. Time really does fly, huh? We hope that 2018 has been good and already have been a learning experience so far.

Formulate your eye drops properly

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Topics: Application Focus, m-VROC, General Information, Proteins, Viscometer, Small Sample Viscometer

Visualizing Viscosity

Posted by Dave Fox

May 16, 2017 10:18:32 AM

One of the challenges of creating monoclonal antibody (mAb) injectable drugs is optimizing formulation. A good formulation has to have a high concentration of stable mAb’s for high efficacy. There are a variety of factors that can affect stability of these mAb’s, temperature, shear forces, pH, and even concentration. When proteins become, unstable and denature they can increase the viscosity of your formulation. Using a simple modified parallel plate demonstration, we can visualize why denatured proteins increase viscosity.

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Topics: Fun with Viscosity, Applications, Biotechnology, Proteins

Not too little, not too much, just the right amount of force

Posted by Grace

Jan 24, 2017 12:41:31 PM

Do you subconsciously dread the first drop of ketchup out of its bottle? Have you noticed the inconsistent flow in the substance as you try to coax the ketchup out, only to have a huge gush of flow when you realize you have coaxed it a little too well? 

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Topics: Proteins, m-VROC, Viscometer, Applications, VROC initium, Biotechnology, Inks Viscosity, Blood Viscosity, Viscosity Measurements

January 25, 2017 | Protein Screening & Intrinsic Viscosity Webinar (Clone)

Posted by Grace

Jan 17, 2017 11:41:04 AM

 

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Topics: Proteins, VROC initium, RheoSense News, RheoSense, Inc.

VROC initium Application Note - Automated Screening of BSA Solutions

Posted by Grace

Apr 27, 2016 5:47:10 PM

VROC® initium
Automated Screening of BSA Solutions

Bovine Serum Albumin (BSA) is a globular protein extracted from cow’s blood. Due to its low-cost, stability and availability, BSA is widely used as a protein concentration standard.
New Call-to-actionRead more about what major applications of BSA include:

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Topics: Pharmaceuticals, VROC Technology, Proteins, Viscometer, RheoSense, Inc., Automatic Viscometer

Viscosity vs. Concentration: L-Arginine Dilute Solutions in Water & PBS

Posted by David Nieto

Mar 15, 2016 4:09:04 PM

 The exact mechanism by which Arginine molecules affect protein molecules in solution is unclear. Nonetheless, its benefits increasing solubility and controlling viscosity have spread out its application in biopharma formulations, specially for high concentration antibody solutions. 

In our application note, we examine the effect of concentration on the viscosity of dilute solutions of L-Arginine in water and PBS. Additionally, we study the Intrinsic Viscosity of this solutions to better understand molecular size and solubility in dilution. 

Download L-Arginine  Application Note

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Topics: Viscosity Measurements, Applications, Biotechnology, Rheometer, m-VROC, Proteins, Viscometer, RheoSense, Inc., Automatic Viscometer, VROC initium, High throughput Viscometer

Seminars to be Hosted in Korea by Insung Chroma-Tech

Posted by RheoSense

Sep 27, 2013 3:36:17 PM

We are excited to announce an upcoming trip to Seoul, Korea by RheoSense CEO & Founder, Dr. Seong-Gi Baek. He will be in Korea to present at two seminars organized by our distributor, Insung Chroma-Tech.

The seminars are entitled "The Importance of Viscosity Measurements in Protein Therapeutics / Industrial / Food."  Please contact us or Insung Chroma-Tech if you wish to attend.


For additional details view PDF.


슬라이드 1

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Topics: Viscosity Measurements, Applications, VROC Technology, General Information, Proteins, Viscometer, RheoSense International Partners, RheoSense, Inc., Conference/Event

Seminar: The Importance of Viscosity Measurements in Protein Therapeutics: Challenges & Solutions

Posted by RheoSense

Jul 12, 2013 12:33:33 PM

South San Francisco Conference Center South San Francisco Conference Center

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Topics: Pharmaceuticals, Biotechnology, m-VROC, Proteins, Viscometer, RheoSense, Inc., Conference/Event

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