A frequently asked question is, "what shear rates should I be using for my measurements?"
Key Words: Face lotion, hand lotion, cream, viscosity, shear thinning, cleaning, high shear, non-Newtonian fluid, protocol, thixotropy
Goal: Cosmetic lotions are often non-Newtonian fluids with yield stresses and thixotropic structure. These properties are vital for their function as self-care products, but also make their rheological properties difficult to characterize. In particular, data collection can be time consuming and instrument cleaning can be challenging. This application note will share an easy-to-implement protocol to precisely measure complex cosmetic formulations using VROC technology.
Working with various CROs and CDMOs, we've come to the question that many companies find themselves asking, "what is the cost of providing the wrong viscosity values to my customers and worse, having them submit the values for FDA approval?"
Our new application note is ready for download! As a sequel to our "Can Your Proteins Take the Heat," we have come out with part 2 where we go into further research on how varying pH with dilute proteins at varied temperatures can impact the viscosity. From there, viscosity values can be used to derive the protein to protein interaction and also the melting transition or protein denaturation process.
Recently, one of my customers brought up a concern that she had seen through other lab instrumentation during her experience in the lab. She asked how we deal with the particular evaporation effects of protein or other samples, especially when it comes to our VROC initium which handles 40 samples or up to 96 samples. So we put it to the test.
What happens when your samples are out on the sample tray for quite some time? When it comes to working with well plate or vial rack systems, your samples could be on the plate/rack for a long time prior to the measurement. As a result, we conducted some studies to see just how much evaporation effects occur specifically with our VROC® technology.
We recently took two commercially available cannabis oil cartridges used to refill cannabis pens and measured the viscosity. The two main differences were the variation in THC and CBD Oils. Sample 1 had 78% THC and 0.29% CBD content. Sample 2 had 80 % THC and 0% CBD.
Excipients are a substance that is often added to protein formulations to serve as a medium for the proteins or active substance in the formulation. While commonly perceived as inert and just a supplement to improve the formulation or become a diluent, adding excipients have sometimes created a reaction of the ingredients in the formulation and according to the NPS Medicinewise article*, such reactions have resulted in various reactions in patients as well.