You may have followed many of our injectability application notes and webinar sessions where we began to explain the concept of calculating injection rates. Our next webinar this coming month on November 20, 2019 at 11:00 am PST will actually be a hands-on live workshop where we will start from scratch on how to approach the calculations to injection rate, figuring out which shear rates to run, and ultimately designing your experiments with the real application in mind.
We hope everyone is doing well as we reach the half-mark of 2018! It is no wonder that May and June tend to be extremely busy, as many of you are preparing for vacation or travel. Make sure to wear sunblock and other preventative measures to keep you from excessive heat & direct exposure from UV rays!
In the upcoming weeks, we are proud to announce the release of our latest application note regarding concentration dependence in protein viscosity. In this app note, Dr. Stacey Elliott gathered viscosity data for Bovine Gamma Globulin (BgG) formulations over the full concentration range, including therapeutic levels ≥ 100 mg/mL, using the VROC®Initium. The solution buffer included sucrose which is a common additive to enhance stabilization during freeze-drying and storage. Relative viscosity versus concentration curves were fit with the Ross-Minton equation which is a frequently used analysis tool for protein formulations.
To view application note, click below!
In case you haven't seen it yet, we released a new app note last week regarding viscosity reduction in protein solutions. In this application note, Dr. Elliott discusses the idea that the viscosity of a protein solution depends on the nature of the individual and protein-protein interaction (PPI). Both of the individual characteristics, such as size and shape, as well as the pair interactions can be influenced by components in the buffer formulation. As a result, it is often desirable to reduce viscosity values so that formulations are suitable for a particular application or process (ie: injection).