Measuring viscosity dates back to as early as the 19th century. French physicist Jean Poiseuille discovered the concept of measuring viscosity by formulating the "mathematical expression for the flow rate for the laminar flow of fluids in circular tubes." Later on, this formulation was discovered by a German hydraulic engineer Gotthilf Hagen, which came to be known as the Hagen-Poiseuille equation (Britannica). Early measurements of viscosity focused primarily on the flow of blood. Measurements were conducted using the hemodynamometer that incorporated narrow tubes & glass capillaries in effort to measure the pressures in the arteries of horses and dogs (Sutera).
Do you subconsciously dread the first drop of ketchup out of its bottle? Have you noticed the inconsistent flow in the substance as you try to coax the ketchup out, only to have a huge gush of flow when you realize you have coaxed it a little too well?
RheoSense is will be exhibiting at the 2016 BioProcessing Summit from August 15 to August 19. Visit us at Booth #101 to meet our specialists and see the newautomatic, high throughput viscometer, VROC® initium!
The exact mechanism by which Arginine molecules affect protein molecules in solution is unclear. Nonetheless, its benefits increasing solubility and controlling viscosity have spread out its application in biopharma formulations, specially for high concentration antibody solutions.
In our application note, we examine the effect of concentration on the viscosity of dilute solutions of L-Arginine in water and PBS. Additionally, we study the Intrinsic Viscosity of this solutions to better understand molecular size and solubility in dilution.
RheoSense is will be exhibiting at the 2016 Society for Laboratory Automation and Screening (SLAS) Conference from January 23rd to the January 27th. Visit us at Booth #601 to meet our specialists and see the new automatic, high throughput viscometer, VROC® initium!
In a recent post, we discussed how some liquids containing bacteria swimmers can display negative viscosity. This can be a misleading since the apparent negative viscosity occurs due to swimmers pushing the surrounding fluid so that the overall system shows negative resistance to flow (i.e. it flows by itself!). One of the best examples of super fluidity is super cooled helium.
Intrinsic viscosity is an important tool in the fields of polymer and protein research. Intrinsic viscosity allows for determination of molecular weight and size more reliably than dynamic light scattering. Small sample m-VROC™ viscometer is an ideal tool to measure intrinsic viscosity of samples. The high accuracy, low sample volume requirements, and high speed of measurement ensure that data collection is fast, simple, and accurate.