Injectability is a common screening criteria when determining the candidacy of protein therapeutics. Often times, the candidate protein therapeutics are scrutinized if the viscosity is higher than the pre-set threshold where the cut off viscosity ranges from 20 to 40 mPa-s depending on the delivery device. However, this type of generalization without specifying the shear rate could potentially lead to a false negative determination of an otherwise excellent therapeutic resulting in significant financial loss and time during development.
Recently, one of my customers brought up a concern that she had seen through other lab instrumentation during her experience in the lab. She asked how we deal with the particular evaporation effects of protein or other samples, especially when it comes to our VROC initium which handles 40 samples or up to 96 samples. So we put it to the test.
Outside of our current pictures or knowledge of the universe lies plasma which is comprised of electrons and nuclei. Due to the lack of knowledge, it is quite difficult to review the behavior of the plasma. However, scientists are aware that the plasma behavior indicates low viscosity behavior resulting in irregularities. Separately, depending on the positioning of the plasma along the magnetic field lines, speculation is that viscosity could vary.
Do you work in the biopharm or biotech industry? Do you work with proteins and currently measure protein viscosity or has the topic come up during conversations and meetings? Many of our customers reference our company not just for viscometers but for the various application notes that we have. We have a wide variety of application notes ranging from ink, oil, cosmetics, and all types of applications which you can explore here:
We recently took two commercially available cannabis oil cartridges used to refill cannabis pens and measured the viscosity. The two main differences were the variation in THC and CBD Oils. Sample 1 had 78% THC and 0.29% CBD content. Sample 2 had 80 % THC and 0% CBD.
Mother's Day is coming up on May 12, 2019. Don't forget to send some appreciation and enjoy a recipe for Angel food cake we found online written by Laura Kurella. She also references 'viscosity,' when explaining the texture of the batter. For convenience, we have copied the recipe below: