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Viscosity of Low concentration Proteins - Electrolyte Solutions

In Applications, application notes

Why you need to measure a full range of shear rates.

A lot of my customers have admitted to measuring viscosity at a shear rate of 1,000 1/s when it comes to formulating various types of drugs including injectables. However, from our recent in-depth analysis of various salt concentrations added to proteins, our results further confirmed why you are not getting your full spectrum when it comes to measuring your proteins at just one and a low shear rate of 1,000 1/s.

  1. Viscosity measurement at wide shear rate range (low to high shear rates) probes Protein to protein interaction and set a better course to formulation optimization of protein therapeutics.    
  2. Accurate injectability estimation requires high shear rate viscosity measurement.  Need to measure viscosity not only at 1000 1/s but also at 100000 1/s.  

If you have any questions or want to learn more, Contact us.

In Applications, Viscometer, RheoSense, Inc.

Various levels of CBD and THC in your Cannabis Oils Vary Viscosity

We recently took two commercially available cannabis oil cartridges used to refill cannabis pens and measured the viscosity. The two main differences were the variation in THC and CBD Oils. Sample 1 had 78% THC and 0.29% CBD content. Sample 2 had 80 % THC and 0% CBD.

In Applications, Application Focus, application notes

Impact of Excipients on Viscosity

Excipients are a substance that is often added to protein formulations to serve as a medium for the proteins or active substance in the formulation. While commonly perceived as inert and just a supplement to improve the formulation or become a diluent, adding excipients have sometimes created a reaction of the ingredients in the formulation and according to the NPS Medicinewise article*, such reactions have resulted in various reactions in patients as well.
Learn how excipients can impact your buffer

In Applications, Proteins, Application Focus, Protein Solutions, protein formulation, application notes

New Publication Announcement - Middle East Respiratory Syndrome Corona-Virus

On April 12, 2019, a new paper, "Effective Vaccination against Middle East Respiratory Syndrome Corona-virus," that focuses on the threat of emerging infectious pathogens and methods to develop vaccines to combat has been published. Diving into further details into pathogens such as Middle East respiratory syndrome corona-virus (MERS-CoV), it is important to understand the history of the disease, MERS.

In Applications, Application Focus, application notes

How To Select Your Desired Shear Rate

One of the most commonly asked questions from our customers is the topic of shear rates and what to expect when dealing with various applications. Now most of you have a general idea on what shear rate means, but we want to take it one step further and illustrate several key components when dealing with shear rates.

In Applications, General Information, RheoSense, Inc., Announcement, FYI, webinar, technical webinar, technical information, Event

"Which RheoSense Chip do I use for my Application?"

One of the common questions we get from our customers is, “Which chip do I use to test my fluid?” RheoSense has a variety of different chips and you may wonder which chip would be the best for your application. The m-VROC® has four different designations of chips: A, B, C, and E. These letter values reference the max pressure capability of the MEMS pressure sensors inside the microfluidic flow cell. With the A-series being able to measure the lowest pressures for low viscosity fluids, the E-series are able to measure the highest pressures for higher viscosities and higher shear rates.

In microVISC, Viscosity Measurements, Applications, VROC Technology, m-VROC, General Information, RheoSense, Inc., VROC initium, Application Focus, FYI

Pot Life

Recently I have been using polyurethane resins for sculpting and casting projects and noticed an interesting term on all of my materials: Pot life. This is something that you see in all kinds of applications from epoxies, silicone, sealants, and building materials. A cursory definition of the term indicated that it was the working life of the material – the cutoff time when you can no longer make adjustments or clean up your projects. However, I found that the material was still very workable beyond the pot life time – in fact for some applications it even worked better.

In Applications, polymer solutions, Expoxies, resins, sculpting, polyurethane