Key Words: Shear Rate Sweep, Shear Thinning, Viscosity, non-Newtonian Fluid, Automation, Newtonian, Characterization, Polymer, Oils
Goal: Serums are a popular self-care product to keep skin healthy. Formulation ingredients can vary dramatically. Some serums use plant-derived ingredients while others use synthetic oils depending on consumer preferences and needs. Thus, serum development is a dynamic process requiring a plethora of characterization experiments to differentiate between formulations. Here we demonstrate that the automated viscometer system, VROC® initium, can perform rate sweeps experiments to characterize different serum formulations based on their rheological properties with minimal engagement.
Viscosity data for alcoholic beverages of various sugar and alcohol percentages was obtained using m-VROC®. The measured viscosity of these commonly consumed beverages was found to be dependent upon the amount of water, alcohol and sugar within the fluid. The viscosity of ethanol water solutions had a parabolic relationship as the amount of ethanol in solution increased. The addition of sugar to alcoholic beverages was also increased the viscosity of these fluids. Shear rate sweeps were performed to confirm Newtonian behavior of alcoholic beverage solutions over the
A lot of my customers have admitted to measuring viscosity at a shear rate of 1,000 1/s when it comes to formulating various types of drugs including injectables. However, from our recent in-depth analysis of various salt concentrations added to proteins, our results further confirmed why you are not getting your full spectrum when it comes to measuring your proteins at just one and a low shear rate of 1,000 1/s.
We recently took two commercially available cannabis oil cartridges used to refill cannabis pens and measured the viscosity. The two main differences were the variation in THC and CBD Oils. Sample 1 had 78% THC and 0.29% CBD content. Sample 2 had 80 % THC and 0% CBD.
Excipients are a substance that is often added to protein formulations to serve as a medium for the proteins or active substance in the formulation. While commonly perceived as inert and just a supplement to improve the formulation or become a diluent, adding excipients have sometimes created a reaction of the ingredients in the formulation and according to the NPS Medicinewise article*, such reactions have resulted in various reactions in patients as well.
On April 12, 2019, a new paper, "Effective Vaccination against Middle East Respiratory Syndrome Corona-virus," that focuses on the threat of emerging infectious pathogens and methods to develop vaccines to combat has been published. Diving into further details into pathogens such as Middle East respiratory syndrome corona-virus (MERS-CoV), it is important to understand the history of the disease, MERS.
One of the most commonly asked questions from our customers is the topic of shear rates and what to expect when dealing with various applications. Now most of you have a general idea on what shear rate means, but we want to take it one step further and illustrate several key components when dealing with shear rates.
One of the common questions we get from our customers is, “Which chip do I use to test my fluid?” RheoSense has a variety of different chips and you may wonder which chip would be the best for your application. The m-VROC® has four different designations of chips: A, B, C, and E. These letter values reference the max pressure capability of the MEMS pressure sensors inside the microfluidic flow cell. With the A-series being able to measure the lowest pressures for low viscosity fluids, the E-series are able to measure the highest pressures for higher viscosities and higher shear rates.