Measuring viscosity at a single and arbitrary shear rate provides limited information which can be difficult to interpret. A much more thorough understanding of a formulation is obtained by measuring the shear rate dependence. In addition to the practical relevance of predicting the behavior during application or processing, the details of a non-Newtonian response reflect the molecular interactions and resulting microstructure at therapeutic levels. Even protein solutions at moderate concentrations can exhibit a Newtonian plateau followed by a shear thinning region illustrating the importance of non-hydrodynamic forces and degree of structure formation.
Intrinsic viscosity has been a parameter commonly used in the waste and recycle process. Based on a recently published article on Engineer Live, about 46% of waste in the oceans have been directed to fishing nets. On top of recycle programs and efforts to reduce the amount of waste, a company called Plastix A/S uses methods to reduce viscosity of the fishing nets which are mainly polyethylene (HDPE). Using compatible polymers, industry developers have been reviewing the potential to use various polymer dynamics to deter a continuous use of material into a method of cycled reuse.
Trilogy Bio, Inc. is hosting a 2019 Emeryville tradeshow where RheoSense, Inc. Technical Specialists will be on-site to help answer any questions.
Our new application note is ready for download! As a sequel to our "Can Your Proteins Take the Heat," we have come out with part 2 where we go into further research on how varying pH with dilute proteins at varied temperatures can impact the viscosity. From there, viscosity values can be used to derive the protein to protein interaction and also the melting transition or protein denaturation process.
It took quite some time but we are proud to announce our customer portal! Through this portal, you can now access software, full manuals, and additional service notes. You will also get a chance to sign up for exclusive product updates, technical application notes, and exclusive scientific data that we are obtaining from our labs!
Last Wednesday, we hosted a new technical webinar where we focus on differentiating low viscosity fluids. If you were unable to attend or would like to access the recording and presentation again, you can now access the full recording.
Injectability is a common screening criteria when determining the candidacy of protein therapeutics. Often times, the candidate protein therapeutics are scrutinized if the viscosity is higher than the pre-set threshold where the cut off viscosity ranges from 20 to 40 mPa-s depending on the delivery device. However, this type of generalization without specifying the shear rate could potentially lead to a false negative determination of an otherwise excellent therapeutic resulting in significant financial loss and time during development.
Measuring small incremental changes in low viscosity samples is challenging. And when we mention low viscosity samples, we mean low (measuring as low as 0.4 or around 1 cP). Our microfluidics based automatic viscometer facilitates this process using a fraction of the volume required for more traditional methods.
Join our webinar where we will present data and analysis to illustrate the following.
A lot of my customers have admitted to measuring viscosity at a shear rate of 1,000 1/s when it comes to formulating various types of drugs including injectables. However, from our recent in-depth analysis of various salt concentrations added to proteins, our results further confirmed why you are not getting your full spectrum when it comes to measuring your proteins at just one and a low shear rate of 1,000 1/s.