<img height="1" width="1" style="display:none;" alt="" src="https://dc.ads.linkedin.com/collect/?pid=510762&amp;fmt=gif">

Why are you disqualifying your potentially great protein candidates

Injectability is a common screening criteria when determining the candidacy of protein therapeutics. Often times, the candidate protein therapeutics are scrutinized if the viscosity is higher than the pre-set threshold where the cut off viscosity ranges from 20 to 40 mPa-s depending on the delivery device. However, this type of generalization without specifying the shear rate could potentially lead to a false negative determination of an otherwise excellent therapeutic resulting in significant financial loss and time during development.

Upcoming Technical Webinar August 28, 2019

Differentiating Low Viscosity Fluids

Measuring small incremental changes in low viscosity samples is challenging. And when we mention low viscosity samples, we mean low (measuring as low as 0.4 or around 1 cP). Our microfluidics based automatic viscometer facilitates this process using a fraction of the volume required for more traditional methods. 
Join our webinar where we will present data and analysis to illustrate the following.

In webinar

Why you need to measure a full range of shear rates.

A lot of my customers have admitted to measuring viscosity at a shear rate of 1,000 1/s when it comes to formulating various types of drugs including injectables. However, from our recent in-depth analysis of various salt concentrations added to proteins, our results further confirmed why you are not getting your full spectrum when it comes to measuring your proteins at just one and a low shear rate of 1,000 1/s.

  1. Viscosity measurement at wide shear rate range (low to high shear rates) probes Protein to protein interaction and set a better course to formulation optimization of protein therapeutics.    
  2. Accurate injectability estimation requires high shear rate viscosity measurement.  Need to measure viscosity not only at 1000 1/s but also at 100000 1/s.  

If you have any questions or want to learn more, Contact us.

In Applications, Viscometer, RheoSense, Inc.