This month, one of our partners in Korea, Insung Chromatech, hosted a seminar in Korea's Science Town. Science Town is a well known area in South Korea for the research & development hub of leading institutes and companies.
Unlike height and weight, which people have a good sense about based on common items, viscosity is much harder to describe.
One of the challenges of creating monoclonal antibody (mAb) injectable drugs is optimizing formulation. A good formulation has to have a high concentration of stable mAb’s for high efficacy. There are a variety of factors that can affect stability of these mAb’s, temperature, shear forces, pH, and even concentration. When proteins become, unstable and denature they can increase the viscosity of your formulation. Using a simple modified parallel plate demonstration, we can visualize why denatured proteins increase viscosity.
As marijuana use becomes more mainstream, the use of vaporizer pens or vape pens as a delivery system for THC is steadily increasing in popularity. Vape pens are not your classic bongs as seen in some old school Cheech and Chong movies, but are in fact a high-tech device; a high-tech device where precision and accuracy are critical to performance.
First of all, the question is-- can there be a coffee or liquid with zero viscosity coffee? We know that there is negative viscosity. Is having zero viscosity similar?
Viscosity is the resistance of a fluid to flow and it comes from the friction of molecules as they move against each other within the fluid. All fluids have at least some resistance to flow – except super fluids.
Do you subconsciously dread the first drop of ketchup out of its bottle? Have you noticed the inconsistent flow in the substance as you try to coax the ketchup out, only to have a huge gush of flow when you realize you have coaxed it a little too well?
The exact mechanism by which Arginine molecules affect protein molecules in solution is unclear. Nonetheless, its benefits increasing solubility and controlling viscosity have spread out its application in biopharma formulations, specially for high concentration antibody solutions.
In our application note, we examine the effect of concentration on the viscosity of dilute solutions of L-Arginine in water and PBS. Additionally, we study the Intrinsic Viscosity of this solutions to better understand molecular size and solubility in dilution.
It is widely accepted that viscosity plays a crucial role in current printing and coating industries. In a very similar way, viscosity has a strong influence on the texture of artistic paintings. Textures may not be as obvious as colors in a painting, but it can be just as important in conveying the artist’s idea or concept behind it.
Intrinsic viscosity is an important tool in the fields of polymer and protein research. Intrinsic viscosity allows for determination of molecular weight and size more reliably than dynamic light scattering. Small sample m-VROC™ viscometer is an ideal tool to measure intrinsic viscosity of samples. The high accuracy, low sample volume requirements, and high speed of measurement ensure that data collection is fast, simple, and accurate.